Acceleron recently announced plans to expand its pipeline into a new therapeutic area; pulmonary disease, with a first indication in pulmonary arterial hypertension (PAH), a rare, progressive and life-threatening blood vessel disorder. The Company recently initiated the PULSAR Phase 2 trial in sotatercept in PAH.
Results from a preclinical trial with sotatercept in PAH demonstrated superior results to standard of care (vasodilators), showing the product candidate’s potential to be a disease-modifying therapy.
Sotatercept is an investigational therapy that is not approved for any use in any country.
|Pulmonary Arterial Hypertension|
Pulmonary Arterial Hypertension
PULSAR TrialPULSAR Trial
SPECTRA Exploratory Trial (Planned)SPECTRA (Planned)
Pulmonary arterial hypertension (PAH) occurs when pulmonary arteries thicken or become rigid, making blood flow more difficult. This causes the heart to work harder to push blood through the arteries, which are no longer able to carry adequate blood to the lungs. As a result, the body doesn’t get the oxygen it needs which causes shortness of breath, chest pain, dizziness, fainting, swelling in arms and legs (edema), chest pressure or pain (angina), and racing pulse.
There is no cure for PAH and often the life expectancy of a PAH patient is between 5-7 years after diagnosis despite a combination of lifestyle changes, medicines (vasodilators), and surgeries which may alter the progression of the disease. Within years, everyday activities such as walking and showering, will eventually become impossible and many patients will require supplementary oxygen.
Based on preclinical results, we believe that sotatercept could be a disease- modifying therapy for PAH. We recently initiated the PULSAR Phase 2 trial in patients with PAH.